Changes in version 1.2.0 (2026-02-17) MAJOR CHANGES: - Leiden Community Detection: Added support for Leiden algorithm as an alternative to hierarchical clustering. Use clustering_method = "leiden" in inferAlleleClusters(). This is particularly useful for D and J segments with variable-length sequences. - Generalized Distance Functions: The new igDistance() function supports multiple distance calculation methods: - "decipher": DECIPHER-based distance (default, best for aligned V segments) - "hamming": Hamming distance (requires equal-length sequences) - "lv": Levenshtein distance (handles variable-length sequences, good for D/J) - Multi-locus Support: inferAlleleClusters() now explicitly supports all V/D/J segments with the locus parameter. - New Visualization Functions: - plotTruncatedTree(): Publication-quality circular tree with collapsed subgroups - plotCommunityNetwork(): Network visualization of cluster relationships - plotSilhouetteOptimization(): Resolution parameter optimization plot - plotClusterComparison(): Compare hierarchical and Leiden clustering results CLASS SYSTEM CHANGES: - S4 to S3 Migration: GermlineCluster is now an S3 class instead of S4. - Access slots with $ instead of @ (e.g., result$alleleClusterTable) - Added print(), summary(), and plot() S3 methods - New slots: clusteringMethod, communityObject, graphObject, distanceMatrix, silhouetteScore, resolutionParameter, locus API CHANGES: - ighvDistance() is deprecated in favor of igDistance() (backward compatible wrapper provided) - ighvClust() is deprecated in favor of igClust() (backward compatible wrapper provided) - inferAlleleClusters() has new parameters but maintains backward compatibility DEPENDENCIES: - Added: igraph, stringdist, cluster, ape - Moved to Suggests: ComplexHeatmap, dplyr, ggtree - Removed from Imports: dplyr (replaced with data.table operations) MINOR CHANGES: - Improved CRAN compliance with proper Author and Maintainer fields - Added test suite using testthat (edition 3) - Redesigned Shiny app with modular architecture - Added Conda recipe for bioconda distribution BUG FIXES: - Fixed deprecated dplyr::between() calls - Fixed deprecated dplyr::bind_rows() calls - Replaced deprecated S4 slot access patterns Changes in version 1.0.7 (2025-04-09) - Working version for CRAN. Changes in version 1.0.6 - An asc_annotation flag was added to inferGenotypeAllele to simplify genotype by asc annotation. Changes in version 1.0.5 - New Feature! We added a confidence level to genotype inference genotype_confidence. The confidence is calculated as the Z score of the allele count, repertoire depth, and the allele absolute threshold. Changes in version 1.0.4 - Fixed bug in download_zenodo_files. Changes in version 1.0.3 - Fixed bug in download_zenodo_files. Changes in version 1.0.1 (2023-08-16) - Fixed bug in download_zenodo_files. - First CRAN release. Changes in version 1.0.0 (2023-06-13) - First release. Changes in version 0.0.1 - Stable version.