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  "Package": "rabhit",
  "Type": "Package",
  "Title": "Inference Tool for Antibody Haplotype",
  "Version": "0.4.0",
  "Authors@R": "c(person(\"Ayelet\", \"Peres\", role=c(\"aut\",\"cre\"), \nemail=\"ayelet.peres@yale.edu\"),\nperson(\"Moriah\", \"Gidoni\", role=c(\"aut\"),\nemail=\"moriah.cohen@biu.ac.il\"),\nperson(\"Gur\", \"Yaari\", role=c(\"aut\",\"cph\"),\nemail=\"gur.yaari@biu.ac.il\"))",
  "Description": "Infers V-D-J haplotypes and gene deletions from AIRR-seq\ndata for Ig and TR chains, based on J, D, or V genes as anchor,\nby adapting a Bayesian framework. It also calculates a Bayes\nfactor, a number that indicates the certainty level of the\ninference, for each haplotyped gene. Citation: Gidoni, et al\n(2019) <doi:10.1038/s41467-019-08489-3>. Peres and Gidoni, et\nal (2019) <doi:10.1093/bioinformatics/btz481>.",
  "License": "CC BY-SA 4.0",
  "URL": "https://github.com/ayeletperes/rabhit,\nhttps://ayeletperes.github.io/rabhit/",
  "BugReports": "https://github.com/ayeletperes/rabhit/issues",
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  "Repository": "https://ayeletperes.r-universe.dev",
  "Date/Publication": "2026-06-19 17:36:41 UTC",
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  "Author": "Ayelet Peres [aut, cre],\nMoriah Gidoni [aut],\nGur Yaari [aut, cph]",
  "Maintainer": "Ayelet Peres <ayelet.peres@yale.edu>",
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    "deletionsByBinom",
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    "geneUsage",
    "hapDendo",
    "hapHeatmap",
    "nonReliableVGenes",
    "plotDeletionsByBinom",
    "plotDeletionsByVpooled",
    "plotHaplotype",
    "readHaplotypeDb"
  ],
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      "name": "GENE.loc",
      "title": "Human Gene order on the chromosome",
      "object": "GENE.loc",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "GERM",
      "title": "Human germlines",
      "object": "GERM",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "HDGERM",
      "title": "Human IGHD germlines",
      "object": "HDGERM",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "HJGERM",
      "title": "Human IGHJ germlines",
      "object": "HJGERM",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "HVGERM",
      "title": "Human IGHV germlines",
      "object": "HVGERM",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "KJGERM",
      "title": "Human IGKJ germlines",
      "object": "KJGERM",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "KVGERM",
      "title": "Human IGKV germlines",
      "object": "KVGERM",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "LJGERM",
      "title": "Human IGLJ germlines",
      "object": "LJGERM",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "LVGERM",
      "title": "Human IGKV germlines",
      "object": "LVGERM",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "samples_db",
      "title": "Example IGH human naive b-cell repertiore",
      "object": "samples_db",
      "class": [
        "data.frame"
      ],
      "fields": [
        "subject",
        "v_call",
        "d_call",
        "j_call"
      ],
      "rows": 223880,
      "table": true,
      "tojson": true
    },
    {
      "name": "samplesHaplotype",
      "title": "Example haplotype inference results",
      "object": "samplesHaplotype",
      "class": [
        "data.frame"
      ],
      "fields": [
        "subject",
        "gene",
        "IGHJ6_02",
        "IGHJ6_03",
        "alleles",
        "proirs_row",
        "proirs_col",
        "counts1",
        "k1",
        "counts2",
        "k2",
        "counts3",
        "k3",
        "counts4",
        "k4"
      ],
      "rows": 444,
      "table": true,
      "tojson": true
    }
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  "_help": [
    {
      "page": "dot-onAttach",
      "title": ".onAttach start message",
      "topics": [
        ".onAttach"
      ]
    },
    {
      "page": "convertToASC",
      "title": "Prepare AIRR-seq data and germline for haplotype inference with allele similarity clusters (ASC)",
      "topics": [
        "convertToASC"
      ]
    },
    {
      "page": "createFullHaplotype",
      "title": "Anchor gene haplotype inference",
      "topics": [
        "createFullHaplotype"
      ]
    },
    {
      "page": "createHaplotypeTable",
      "title": "Create haplotype table",
      "topics": [
        "createHaplotypeTable"
      ]
    },
    {
      "page": "deletionHeatmap",
      "title": "Graphical output of single chromosome deletions",
      "topics": [
        "deletionHeatmap"
      ]
    },
    {
      "page": "deletionsByBinom",
      "title": "Double chromosome deletion by relative gene usage",
      "topics": [
        "deletionsByBinom"
      ]
    },
    {
      "page": "deletionsByVpooled",
      "title": "Single chromosomal D or J gene deletions inferred by the V pooled method",
      "topics": [
        "deletionsByVpooled"
      ]
    },
    {
      "page": "GENE.loc",
      "title": "Human Gene order on the chromosome",
      "topics": [
        "GENE.loc"
      ]
    },
    {
      "page": "geneUsage",
      "title": "Double chromosome deletion by relative gene usage",
      "topics": [
        "geneUsage"
      ]
    },
    {
      "page": "GERM",
      "title": "Human germlines",
      "topics": [
        "GERM"
      ]
    },
    {
      "page": "hapDendo",
      "title": "Hierarchical clustering of haplotypes graphical output",
      "topics": [
        "hapDendo"
      ]
    },
    {
      "page": "hapHeatmap",
      "title": "Graphical output of alleles division by chromosome",
      "topics": [
        "hapHeatmap"
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    },
    {
      "page": "HDGERM",
      "title": "Human IGHD germlines",
      "topics": [
        "HDGERM"
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    },
    {
      "page": "HJGERM",
      "title": "Human IGHJ germlines",
      "topics": [
        "HJGERM"
      ]
    },
    {
      "page": "HVGERM",
      "title": "Human IGHV germlines",
      "topics": [
        "HVGERM"
      ]
    },
    {
      "page": "KJGERM",
      "title": "Human IGKJ germlines",
      "topics": [
        "KJGERM"
      ]
    },
    {
      "page": "KVGERM",
      "title": "Human IGKV germlines",
      "topics": [
        "KVGERM",
        "LVGERM"
      ]
    },
    {
      "page": "LJGERM",
      "title": "Human IGLJ germlines",
      "topics": [
        "LJGERM"
      ]
    },
    {
      "page": "nonReliableVGenes",
      "title": "Detect non reliable gene assignment",
      "topics": [
        "nonReliableVGenes"
      ]
    },
    {
      "page": "plotDeletionsByBinom",
      "title": "Graphical output of double chromosome deletions",
      "topics": [
        "plotDeletionsByBinom"
      ]
    },
    {
      "page": "plotDeletionsByVpooled",
      "title": "Graphical output for single chromosome D or J gene deletions according to V pooled method",
      "topics": [
        "plotDeletionsByVpooled"
      ]
    },
    {
      "page": "plotHaplotype",
      "title": "Graphical output of an inferred haplotype",
      "topics": [
        "plotHaplotype"
      ]
    },
    {
      "page": "rabhit",
      "title": "The RAbHIT package",
      "topics": [
        "rabhit"
      ]
    },
    {
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      "title": "Read a Change-O tab-delimited database file",
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    },
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      "title": "Example IGH human naive b-cell repertiore",
      "topics": [
        "samples_db"
      ]
    },
    {
      "page": "samplesHaplotype",
      "title": "Example haplotype inference results",
      "topics": [
        "samplesHaplotype"
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      "source": "RAbHIT-vignette.Rmd",
      "filename": "RAbHIT-vignette.pdf",
      "title": "RAbHIT: R Antibody Haplotype Inference Tool",
      "author": "Ayelet Peres & Moriah Gidoni & Gur Yaari",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Introduction",
        "Input",
        "Pre-processing of the data",
        "Running RAbHIT",
        "Infer haplotype by anchor gene",
        "Haplotype with J6 as anchor",
        "Haplotype with D2-21 as anchor",
        "Compare multiple haplotypes",
        "Inferring double chromosome deletion by relative gene usage",
        "Interactive Haplotype inference with double chromosome deletions",
        "Haplotype inference deletion heatmap",
        "Inferring D/J single chromosome deletion by V pooled approach",
        "Contact",
        "References"
      ],
      "created": "2018-10-22 16:38:39",
      "modified": "2021-11-30 12:39:33",
      "commits": 22
    }
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